Each ml contains 333 mg Sulfadimidine sodium.
Sulfadimidine sodium is a broad spectrum sulfonamide. In competition with para aminobenzoic acid, sulfadimidine causes folic acid inhibition and stops protein synthesis. Therefore sulfadimidine is a bacteriostatic agent. After oral administration, drug is quickly absorbed from digestive system and well diffused into the body tissues. Quick absorption and long-term stability in blood are resulted in desirable therapeutic effect. Sulfadimidine is involved in metabolic changes (acetylation and conjugation) especially in liver and its main part is excreted by urine and few amount is excreted by feces, bile, sweating and milk.
Sulfadimidine sodium has a broad antimicrobial spectrum on gram negative and gram positive bacteria such as: Streptococcus, Staphylococcus, Bacillus anthracis, Clostridium tetani and perfringens, E.coli, Salmonella, Pasteurella, Chlamydia, Nocardia and Protozoa like Coccidia and Toxoplasma. Some species of Pseudomonas, Leptospria and Proteus are relatively resistant to sulfadimidine.
Sulfadimidine sodium (as oral) is used for treatment of systemic infections in cattle.
Cattle: Calf diphtheria, foot rot, actinobacillosis, metritis, polyarthritis, coccidiosis and mastitis.
Cattle: Start with 220 mg sulfadimidine per kg body weight in first day (30 ml of solution per 50 kg body weight) then 110 mg sulfadimidine per kg body weight in 2nd, 3rd and 4th days (15 ml of solution per 50 kg body weight).
Cattle and calves: 10 days
Milk: 4 days
Should not be used with antacid drugs, Ca salts and vit. K.
Lactating cows more than 20 months old, calves under one month, in hepatic and renal failures and drug sensitivity.
Do not use more than 7 consecutive day. It is recommended to add compositions which change water taste to increase water and drug consumption.
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