Each ml contains 50 mg oxytetracycline hydrochloride.
Oxytetracycline is obtained from Streptomyces rimosus. Oxytetracycline prevents protein synthesis of growing bacteria and do this via attaching to aminoacyl transfer RNA (aa-tRNA) on ribosomal 30s unit and also this drug reduces conversion of glutamate to cellular protein which inhibits bacterial growth .Tetracyclines affect on ribosomal 50s unit and change permeability of susceptible bacteria. Effective plasma concentration of oxytetracycline is achieved 15 minutes after intramuscular injection and reaches to peak after 1 hour. PAE (post antibiotic effect) remains about 12 hours, and the concentration is reduced 24 hours after injection gradually .Drug diffusion in body is very wide . After absorption, it can be detected in the heart, kidney, lungs, muscles, pleural fluid, lung secretions, bile, saliva, urine and synovial fluid. Its diffusion in CSF is low but passes from placenta easily. The volume of diffusion of this drug is 0.8 l/kg in cow, 4.1 l/kg in horse and 1.2 l/kg in small animals. Rate of attachment of this drug to plasma protein is 10-40 percent. Oxytetracycline is excreted from kidney without change. Therefore it is useful for treatment of urinary infections. Oxytetracycline is not metabolized and enters into digestive system via bile and chelates with substances in faeces.
Oxytetracycline is a broad spectrum antibiotic which affects on large number of Gram positive and Gram negative bacteria .In general, this drug is effective on Mycoplasma spp., Spirochetes, Chlamydia and Rickettsia spp. and also on some strains of Staphylococcus and Streptococcus. Gram positive bacteria which are sensitive to tetracycline include Actinomyces, Bacillus anthracis, Clostridium perferingens, Clostridium tetani, Listeria monocytogenes and Nocardia.
Gram negative bacteria which are sensitive to this drug include Bordetella, Brucella, Bartonella, Haemophilus, Pasteurella multocida, Shigella and yersinia pestis.
In general, this drug is used for treatment of these diseases:
1) Cattle, sheep and goats:
Infections of urogenital system: Metritis, Mastitis, Pyelonephritis, Cystitis and retained placenta.
Infections of respiratory system: Pneumonia, Pleuresia, Infectious ovine pleuropneumonia and Pasteurellosis (Shipping fever).
Other infectious diseases: Anaplasmosis, Agalaxia, Leptospirosis, Salmonellosis, Brucellosis, Anthrax, Enterotoxemia, Foot rot, Actinomycosis, Actinobacillosis and postoperative infections.
2) Horse: Polyarthritis like lyme disease, Strangel, Enteritis, and Pneumonia.
This drug is used through intramuscular, intravascular and subcutaneous routes. In toxemia cases, intravascular injection of this drug decreases shock incidence. Intravascular injection is done only once a day but in acute cases it could be done twice a day (every 12 hours).Suggested dosage is 5 -10 mg/kg bodyweight for 4-5 days (4-10 ml per 45kg bw).
Beef: 14 days after last injection.
Milk: 5 days after last injection.
Do not use with penicillin.
Do not use in animals which are sensitive to this drug and also in animals with renal and hepatic failure. Muscular injection should be done slowly and second injection is done in other site. Do not inject more than 10 ml in one site. Intraspinal injection of this drug is very dangerous but in acute infections it is possible with caution. Because of effects of this drug on fetus, it should be used in second half of pregnancy cautiously.
Long term use of this drug in young animals can be resulted in bones and teeth color changing into yellow, brown and gray.
It is possible to appear local reaction and necrosis in injection site. Quick intravenous injection causes arrhythmia and collapse.
Keep below 30º C and away from direct light.
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