Ormethoxine


Sulfadimethoxine 25% + Ormetoprim 5%

ارمتوکسین® | ORMETHOXINE
  • - animals:
  • - Packaging:
  • 1 and 5 kg aluminum packs

Product properties

Composition

Sulfadimethoxine+ Ormetoprim premix contains 30% active ingredients (250 g/kg SDM and 50 g/kg OMP)

Mechanism of Action:

The potentiated sulfa drug Ormethoxine premix interferes with folic acid production, an essential substance for cell wall synthesis of the bacteria. This takes place on two vital steps. Sulfadimethoxine (SDM) prevents the formation of dihydrofolic acid from para-aminobenzoic acid (PABA) and pteridine. Ormetoprim (OMP) interferes in the following step of transferring dihydrofolic acid into tetrahydrofolic acid, both important steps in the synthesis of bacterial cell walls. As a result, bacteria unable to successfully form cell walls will die allowing the host aquatic animal to overcome the disease.

Ormethoxine premix are recognized as very effective against a wide variety of gram positive and gram negative bacteria like Vibrio, Aeromonas, Edwardsiella and Staphylococcus strains in salmon and trout.

Indications of use

Control of enteric septicemia caused by Edwardsiella ictaluri  and furunculosis caused by Aeromonas salmonicida in salmon and trout.

Dosage and route of administration

Establish the weight of the fish to be treated. Calculate the amount of feed needed to feed the fish per day according to fish size and water temperature (or recent actual feeding rates). 16.7 grams of Ormethoxine premix is needed per 100 kg of fish weight per day (= 50 mg active ingredient per kg body weight eating 1kg feed per day), as described in Table1. For addition of Ormethoxine premix to feed after pelletization or extrusion, prepare a slurry by suspending Ormethoxine premix in a 5% gelatin solution. Do not use oils as oils tend to bring out the bitter taste of ormetoprim. Gently coat the pelleted feed with the slurry and allow drying for several hours before storage. As a general rule, 1 liter of slurry is required to coat 25 kg of pellets. Refer to dosage levels in Table 2 for recommended level of use

Daily feed intake(per cent of body weight) Ormethoxine per metric ton feed (kg) Biomass fish, shrimp medicated per ton of feed 5 days treatment (kg)
1 16.7 20000
2 8.4 10000
3 5.6 6667
4 4.2 5000
5 3.3 4000
6 2.8 3333
Table 1 – weight for 5 days Ormethoxine premix for mixing into the feed 50mg / kg body
Daily feed intake(per cent of body weight) Ormethoxine premix per liter slurry(gram) Biomass (fish,shrimp medicated per ton of feed 5 days treatment (kg)
1 417 20000
2 208 10000
3 139 6667
4 104 5000
5 83 4000
6 69 3333
Table 2 – Ormethoxine premix for coating of pellets (on the farm use). 1 liter slurry per 25 kg feed (40 liter per ton).50 mg / kg body weight for 5 days.
Daily feed intake(per cent of body weight) Ormethoxine per metric ton feed(kg) Biomass (fish,shrimp)medicated per ton of feed 5 days treatment
1 5.01 7143
2 2.52 3571
3 1.68 2381
4 1.28 1786
5 0.99 1428
6 0.84 1190
Table 3 – Ormethoxine as a parasiticide for controlling ich and crypto. 15 mg per kg body weight for 14 days.

Withdrawal Time

42 days(in water above 10 degree Celsius)

Precautions

When handling the product, use proper personal protective equipment

like gloves, anti dust mask and  safety glasses as it leads to sever eye reaction.

In case of accidental eye  exposure ,wash the place  with plenty of  water.

Avoid skin contact strictly.

Keep out of reach of children.

Storage conditions

Store out of direct sunlight in a well ventilated area at room

temperature