Each ml of Ivermectin injectable solution contains 10 mg Ivermectin
Ivermectin is a member of the macrocyclic lactone class. Ivermectin acts as agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of neuronal signals of the parasites, which are either paralyzed and expelled out of the body, or they starve. Paralysis and death of the parasite is as the result of an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell.
In mammals the GABA receptors occur only in the central nervous system (CNS), i.e. in the brain and the spinal cord. But mammals have a so-called blood-brain barrier that prevents microscopic objects and large molecules to get into the brain. Consequently macrocyclic lactones are much less toxic to mammals than to the parasites that do not have such a barrier, which allows quite high safety margins for use on livestock. Since flukes and tapeworms do not use GABA as a neurotransmitter Ivermectin is ineffective against these parasites.
Iver 1® is indicated for the effective treatment and control of internal and external parasites in different species of animals.
Cattle and Sheep: For control and prevention of gastrointestinal roundworms (strongylus spp.), lungworms, grubs, sucking lice, mange ,mites, nasal parasite (Gastrophylus nasalis) and ocular parasite (Thelazia)
only with veterinarian prescription.
Cattle and Sheep: 1ml/50 kg BW
Iver 1® Injection should be given subcutaneously only. Inject under the loose skin in front of or behind the shoulder in cattle and in the neck in front of the shoulder in sheep.
Meat: 35 days
The intravenous or intramuscular injection must be avoided .The accidental intramuscular injection leads to side effects such as midline and limbs edema ,fever and sudden deatj.
The drug should be used only in fattening animals and its administration in animals that their milk is for human consumption is forbidden. The drug should be discontinued in pregnant animals 2 month before parturition.
To reduce risk of potentially fatal clostridial infection of the injection site ,the sterility must be considered. In the case of infection the proper antibiotics must be used .The transient pain and edema may occur at the site of injection. This drug is effective against hypodermal larve but during treatment some side effect such as mouth discharge and tympany (if the larves are at throat) and paralysis and circling(if the larves are at spinal cord) may occur. It is recommended to vaccinate the sheep against enterotoxemia before injection of Ivermectin. For complete treatment of mites in sheep the dose must be repeated 7 days later
When Ivermectin comes in contact with the soil, it readily and tightly binds to the soil and becomes inactive over time. Free Ivermectin may adversely affect fish and certain water-borne organisms on which they feed. For this reason dispose the empty containers in an approved landfill or by incineration.
Keep away from direct sunlight and freezing.
Store below 25 Cº.
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