Enrofloxacin 10% Rooyan

Each ml contains: Enrofloxacin   100 mg

Enrofloxacin is a broad spectrum and bactericidal antibiotic that belongs to fluoroquinolones that prevents DNA transcription via  inhibiting DNA Gyrase enzyme activity and converts DNA to small and inactive parts which result in bacterial death. This drug is used for controlling and treatment diseases caused by aerobic Gram negative bacilli and cocci (E. Coli, Salmonella, Pasteurella and Haemophilus) and Gram positive bacteria (Staphylococcus, Streptococcus, Corynebacterium, Clostridium, Listeria monocytogenes) and also Mycoplasma spp.

After injecting 2.5 mg/kg calf bodyweight,  Enrofloxacin concentration reaches to 0.9 mg per ml of blood serum after 1 hour but its concentration in tissues such as lungs, heart, liver, kidney and lymphatic system is 2 or 3 times more than its concentration in CSF.

This drug is excreted via kidney and non-kidney route (15-50 percent of this drug is excreted via urine through both tubular secretion and glomerular filtration) without any change in the molecule. The rest of drug is excreted via faeces. Half life of drug is 3 hours.

Enrofloxacin 10% is used for treatment of diseases caused by Gram positive and Gram negative bacteria and Mycoplasma spp. and also some of secondary infections following viral diseases. It is applied for treatment of infection in

urinary, respiratory and digestive systems, skin and soft tissues.

Enrofloxacin in calf, cow, sheep, goat and rabbit is used often for treatment of digestive infections (Salmonellosis, Colibacillosis and Pasteurellosis) and respiratory infections (bronchopneumonia, pleuropneumonia and mycoplasma infections). In dog and cat it is used for treatment of external ear infections and osteomyelitis.

Cattle, sheep and goats: 2.5 mg/kg bodyweight through subcutaneous injection (0.25 ml per 10 kg bodyweight). In cases such as severe infectious complications in lungs, salmonellosis and contagious agalactia, dosage should be twice as much as above suggested dose. Period of treatment is recommended to be 3 days for normal cases and 5 days for acute cases.

Beef: 7 days after last injection.

Milk: 4 days after last injection.

Do not use during growing period because it may cause damages in chondroid tissues and joints.

Do not use in dogs less than 1 year of age and cats less than 8 months of age.

Keep between 15-25º C and away from direct light.