Each ml contains 180 mg of danofloxacin as the mesylate salt.
Danofloxacin mesylate is a synthetic fluoroquinolone antimicrobial agent. Danofloxacin exerts its activity by inhibiting the bacterial DNA gyrase enzyme, thereby blocking DNA replication. Inhibition of DNA gyrase is lethal to bacteria and danofloxacin has rapid bactericidal effect. Danofloxacin 18% is active against gram negative and gram positive bacteria.
Danofloxacin 18% has been shown to be effective in the treatment of bovine respiratory disease associated with Pasteurella (Mannheimia) haemolytica and Histophilus somni and E.coli in calves diarrhea and bovine mastitis.
– For treatment of bovine respiratory disease (BRD) associated with Mannheimia-haemolytica and Pasteurella multocida and Histophilus somni
– For treatment of acute coliform mastitis
– For treatment of diarrhea because of colibacillosis in calves
Single-Dose Therapy (BRD treatment and control in cattle at high risk conditions):
Administer subcutaneously at 8 mg/kg of body weight (1 mL/22.5kg) as a one-time injection.
Multi-Day Therapy (BRD treatment, treatment of acute coliform mastitis, treatment of diarrhea because of colibacillosis in calves):
Administer subcutaneously or intravenously at 6 mg/kg of body weight (1mL/30kg) with this treatment may be repeated once approximately 48 hours following the first injection if necessary.
Meat: 8 days
Milk: 4 days
Laboratory studies have shown that using Danofloxacin 18% concomitantly with bacteriostatic antibiotics like tetracycline, macrolides and phenicols have antagonistic effect.
Care should be taken to dose accurately. Over dose can produce erosions of cartilage of weight bearing joints. In animals with articular disease or cartilage dystrophy should administer carefully. In animals with a history of hypersensitivity to quinolones should avoid administer this product. Administered dose volume should not exceed 15 ml per injection site.
Subcutaneous injection can cause a transient local tissue reaction which can last up to 30 days. In humans in case of dermal contact, wash skin with soap and water.
There is a risk of photosensitization within a few hours after excessive exposure
to quinolones. If photosensitization occurred, avoid direct sunlight.
Store at or below 30°C.
Protect from light.
Protect from freezing.
Keep out of reach of children.
The color is yellow to amber and does not affect potency.
After the first opening the vial the shelf life is 28 days.
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