- - animals:
- - type:
- antibiotics
- - usage:
- injectable sterile solution
- - manufacturer:
- Rooyan Darou
- - Packaging:
- 50 ml vials
Product properties
Composition
| Each ml contains: | |
| Sulfadiazine (sodium) | 200 mg |
| Trimethoprim | 40 mg |
Mechanism of Action:
This drug is combination of a type of sulfonamide (sulfadiazine) and diaminopyrimidine (trimethoprim) that inhibits PABA enzyme in folic acid synthesis process which results to stop bacterial vital activity. Both of these substances have synergistic effect that lead to inhibits dihydrofolic acid formation which is necessary for nucleic acid synthesis.
Indications of use
In treatment of acute, sub acute and chronic diseases susceptible to sulfadiazine and trimethoprim in horse, cattle, dog and cat. Therapeutic spectrum of this drug includes some species of Staphylococcus, Streptococcus, E.Coli, Actinobacillus, Actinomyces, Klebsiella, Listeria monocytogenes, Salmonella, Proteus mirabilis, Pasteurella, Enterobacter aerogenes, Haemophilus influenza, Vibrio, Brucella and Corynebacteriums. It is effective in trearment of urogenital, digestive and respiratory infections also in laminitis, synovitis, mastitis and eye, ear and mouth infections.
Dosage and route of administration
Cattle: 1 ml per 16 kg body weight through IM or slow IV injection
Horse: 1 ml per 16 kg body weight through slow IV injection.
Dogs and cats: 1 ml per 8 kg body weight through subcutaneous route.
Recommended place for injection in dog is dorsal skin of neck.
Withdrawal Time
Beef: 10 days after the last injection.
Milk: 3 days after the last injection.
Contraindications
Do not use in animal with renal or hepatic failure and also in case of hypersensivity to sulfonamides.
Precautions
Long term usage leads to folic acid reduction, blood dyscrasia and crystalluria. Local inflammation in injection site and shock after rapid intravenous injection are possible.
Storage conditions
Keep between 15-25° C and away from direct lights.
