Ivermectin + Closantel


Ivermectin + Closantel

درمان ترماتودها ( فلوك)
  • - animals:
  • - Packaging:
  • 50 &100 ml vials

Product properties

Composition

Each ml contains Ivermectin 5 mg and Closantel

(as closantel sodium dihydrate) 125 mg

Mechanism of Action:

lvermectin belongs to Avermectins family which inhibits the GABA actions by interrupting of neurotransmitter in post synapses on the other hand Closantel reacts with energy metabolisms of the helminthes. It uses as a sodium salt. One dose of Closantel plus lvermectin solution Injection effectively controls internal and external parasites that impair the health and productivity of cattle. This is a combination of two potent anti-helminthic drugs, Closantel & lvermectin, with a good efficacy and good covers for this medication. Closantel plus lvermectin solution for injection uses a unique mixture of ivermectin (for the treatment of lice, worms and ticks) and Closantel (for the treatment of liver nuke and gastrointestinal roundworms). Clasantel plus lvermectin solution for injection is the only combined injection that has a high efficiency rate against late immature and mature fluke. Closantel plus lvermectin Injection treats mixed liver fluke and nematode or arthropod infestations due to gastrointestinal roundworms, lungworms, eye worms, warbles, mites and lice of cattle, weanlings and stickler cows. Closantel plus lvermectin solution for injection may also be used as an aid in the control of the biting louse Damalinia bovis and the mange mite Chorioptes bovis, but complete elimination may not occur.

Indications of use

Cattle: For the treatment of mixed trematode (fluke) and nematode or arthropod infestations

due to gastrointestinal roundworms, lungworms, eye worms, warbles, mites and lice of cattle.

Sheep: For the treatment of mixed trematode (fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, trematodes, lungworms, nasal bots and mites of sheep.

Dosage and route of administration

This product should be administered at a dosage rate of 200 mg ivermectin per kg bodyweight and 5mg closantel per kg bodyweight (1ml per 25kg). It should only be injected subcutaneously into the neck. A maximum dose of 10ml should be administered at any one site with any residual volume administered at another site in the neck. For the treatment and control of sheep scab an injection of this product for Sheep may be administered but must be followed with a second injection of an ivermectin only product seven days after the initial injection to treat clinical signs of scab and to eliminate mites. This injection should be administered at the other side of the neck.

Contraindications:

Do not administer concomitantly with chlorinated compounds. The effects of GABA agonists are increased by ivermectin. This product is not for intravenous or intramuscular use.

Side effects:

Transitory discomfort has been observed in some cattle following subcutaneous administration. Tissue swellings at the injection site are common up to 48 hours after injection which resolve thereafter without treatment. Hardness on palpation may be observed up to 7 days following administration. Transitory swelling has occasionally been observed in sheep at the injection site. Occasionally this swelling is

accompanied by pain and discomfort. This swelling completely resolves within 14 days of treatment. Avermectins may not be well tolerated in all non-target species (cases of intolerance with fatal outcome are reported in dogs – especially Collies, Old English Sheep dogs and related breeds or crosses, and also in turtles/tortoises).

Withdrawal Time

Cattle Meat and Offal: 49 days.

Milk: Not authorized for use in cattle producing milk for human consumption including during the dry period. Do not use during the last trimester of pregnancy in heifers which are intended to produce milk for human consumption.

Sheep Meat and Offal: 28 days

Milk: Not authorized for use in ewes producing milk for human consumption including during the dry period.

Do not use within 1 year prior to the first lambing in ewes intend to produce milk for human consumption.

Recommendations:

This product can be administered to cattle and sheep at any stage of pregnancy or lactation provided that the milk is not intended for human consumption.

Precautions

Do not administrate over dose.

Special precautions to be taken by the person administering the medical veterinary

product to animals:

Do not smoke, eat or drink while handling the product. Avoid direct contact of the product with the skin. In case of spillage on to the skin rinse immediately with fresh water. Wash hands after use. Take care to avoid self-injection. Inadvertent self-injection may result in local irritation and/or pain at the injection site. In case of accidental self-injection, seek medical advice immediately and show the package leaflet to the physician.

Storage conditions

Do not store above 25º C. Protect from light.

Keep out of reach and sight of Children.

Shelf-life after first opening of immediate packaging: 28 days.